PIK3CA and acute lymphoblastic leukemia: Despite the low overall number of cooperating mutations among patients with infant ALL, the high frequency of mutations in the tyrosine kinase/PI3K/RAS signaling pathways were identified, including recurrent ones in KRAS and NRAS, and also non-recurrent mutations in FLT3, NF1, PTPN11, and PIK3R1 [123,124].