Among Ph-like B-ALL, CRLF2 rearrangements are equally common and consist of a translocation of the immunoglobulin heavy chain gene IGH to CRLF2 (IgH::CRLF2) or fusion due to an interstitial deletion of the PAR1 region centromeric to CRLF2 in chromosomes X and Y (P2RY8::CRLF2) [83]. Here, CRLF2 is linked to acute lymphoblastic leukemia.