When Spata18 knock out mice were crossed with ApcMin/+ mice, which are known to develop multiple benign tumors in the small intestine [23,24], Spata18-deficient ApcMin/+ mice showed a much shorter lifespan with a higher number and size of intestinal tumors compared with Spata18-WT ApcMin/+ mice [9]. This evidence concerns the gene SPATA18 and intestinal neoplasm.