IL17A and autoimmune disease: Brucklacher et al. revealed that XBP1-s deficiency suppresses naive T cell differentiation towards Th17 cells, as well as the expression of interleukin-17 (IL-17) and retinoic acid receptor (RAR)-related orphan receptor γt (RORγt), two Th17 expression products which are associated with inflammatory and autoimmune diseases.