During the development of ovarian cancer, activation of the IRE1α/XBP1-s pathway by glucose deficiency-induced ER stress suppresses the expression of glutamine transporters’ solute carrier family 1 member 5 (SLC1A5), solute carrier family 38 member 1 (SLC38A1), and solute carrier family 38 member 2 (SLC38A2). Here, XBP1 is linked to ovarian carcinoma.