In another example of cancer gene therapy strategy, adipose MSCs have been modified to release a soluble trimeric and multimeric variant of known anti-cancer TNF-related apoptosis-inducing ligand (sTRAIL) soluble anti-cancer factors, which could lead to apoptosis in the cell lines of primary pancreatic ductal adenocarcinoma [99]. Here, TNFSF10 is linked to cancer.