Furthermore, the concomitant expression of AML1-ETO (AML1-ETO, a fusion product of the chromosomal translocation t(8;21)(q22;q22)) usually occurs in acute myeloid leukemia (AML) with granulocytic differentiation, FAB M2 subtype [113], and Ventx induced the expression of the erythroid markers, leading to AML in all transplanted mice. This evidence concerns the gene RUNX1 and acute myeloid leukemia.