In the present study, we investigated whether pharmacological induction of arterial stiffness and hypertension with angiotensin II (1 μg·kg−1·min−1 for 28 days via an osmotic minipump) impairs the progression of Alzheimer’s disease in two mouse models (hAPP23+/− and hAPPswe/PSEN1dE9 mice). This evidence concerns the gene AGT and hypertensive disorder.