GRHL3 and Anxiety: Neural tissue-specific conditional deletion of Grhl3 (using Nestincre-mediated recombination of a floxed-Grhl3 allele) resulted in aberrations in locomotor activity and decreased anxiety-like behaviours but did not show any defects in neurogenesis, neural patterning and neurotransmitter (tyrosine hydroxylase) release, stem cell proliferation or apoptosis [120].