GRHL3 and spina bifida: Unlike the majority of genes that are implicated in the aetiology of neural tube defects in mice, but not in humans, genetic variations in human GRHL3 do indeed present with numerous congenital defects, particularly in craniofacial development (reviewed in [16]), but also in the aetiology of spina bifida, highlighted by a study that identified eight deleterious variants in GRHL3 in a large sequencing study of human spina bifida cases [113].