Since we identified the first GABRA1 mutation, A322D, in an epilepsy patient two decades ago [42], there have been more than 25 GABRA1 mutations that are related to pediatric encephalopathy reported, such as T20I, V74I, S76R, F104C, R112Q, N115D, L146M, T156C, P181S, D219N, P260L, S270H, V287L, T292I, K306T A322D, A332V, as well as R214H/C, G251S/D, M263T/I, and T289P/A, in which the same residue is replaced by different amino acids [8,13,21,25,35,43]. Here, GABRA1 is linked to epilepsy.