SATB2 and NRG1 are engaged in the activation of WNT/β-catenin, transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin-like growth factor-I (IGF-1) signaling pathways which are related to the pathogenesis of UFs [23]. The gene discussed is IGF1; the disease is Ochoa syndrome.