Accordingly, experimental data imposing time-restricted feeding (TRF) to Drosophila melanogaster flies is able to counteract obesity-induced dysmetabolism and improves muscle performance (e.g., suppressing intramuscular fat deposits, phospho-AKT level, mitochondrial alterations, and markers of insulin resistance), involving sphingosine kinase 2 (Sk2), which modulates ceramides production [61]. This evidence concerns the gene SPHK2 and obesity disorder.