In the FINRISK 2002 study, four ceramides Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1) were analyzed, and the most significant predictor both in univariate and multivariable analyses for incidence of type 2 diabetes was the Cer(d18:1/18:0)/Cer(d18:1/16:0) ratio [55]. Here, CBLN1 is linked to type 2 diabetes mellitus.