SPHK2 and obesity due to melanocortin 4 receptor deficiency: Accordingly, experimental data imposing time-restricted feeding (TRF) to Drosophila melanogaster flies is able to counteract obesity-induced dysmetabolism and improves muscle performance (e.g., suppressing intramuscular fat deposits, phospho-AKT level, mitochondrial alterations, and markers of insulin resistance), involving sphingosine kinase 2 (Sk2), which modulates ceramides production [61].