HIF-1-mediated mRNA upregulation of glucose transporter 1 (GLUT1), lactate dehydrogenase A (LDHA), and pyruvate kinase isoform M2 (PKM2) required NOX4-derived ROS production to promote glycolytic switch in thyroid and in diverse non-small cell lung cancer cell lines [92,146]. The gene discussed is LDHA; the disease is non-small cell lung carcinoma.