Importantly, it has been found that, in non-CF airway epithelial cells, NHERF1 and ezrin are mostly located close to the apical region, while in CF cells, they rather localize to the cytoplasm, which is suggestive of the fact that somehow, CFTR must promote the polymerization of actin monomers needed to establish a well-organized actin cytoskeleton (Figure 1). The gene discussed is NHERF1; the disease is cystic fibrosis.