IL33 and infection: In response to infection or tissue injury, IL-33 precursor is cleaved by caspase-1 to form an active secreted IL-33, which in turn activates mast cells, basophils, and group 2 innate lymphoid cells (ILC2) to secrete IL-4, IL-5, and IL-13 via the receptor suppression of tumorigenicity 2 (ST2) [21].