Therefore, the understanding of pathological feedback between AD and T2DM is enhanced by elucidating the molecular relationships between amylin and β-amyloid, as it appears that amylin found in the brains of patients with AD [134,136] may cause amyloid formation [134,135,136,137,138,139,140,141,142] through heterologous interaction. Here, IAPP is linked to type 2 diabetes mellitus.