Aberrant regulation of TLRs has been frequently reported to be involved in oncogenesis, such as the participation of TLR3 in neuroblastoma, breast cancer, hepatocellular carcinoma, nasopharyngeal cancer and lung cancer [168], and the overexpression of TLR4 in lung cancer, neuroblastoma, colorectal cancer and thyroid cancer [169]. The gene discussed is TLR3; the disease is neuroblastoma.