STAT3 and head and neck squamous cell carcinoma: Honokiol, isolated from the bark, seed cones and leaves of the trees of the genus Magnolia, could inhibit EGFR in head and neck squamous cell carcinoma (HNSCC) cells, resulting in reduced activities of its downstream proliferative and survival targets, such as AKT, STAT3, BCL-XL and cyclin D1.