Mutation in parkin encoding gene park2, is associated with autosomal recessive Parkinson’s disease [100]. The E3 ubiquitin ligase activity of parkin is amplified upon protective sulfhydration, which facilitates mitophagy. Ubiquitin specific peptidase 8 (USP8) is required for the recruitment of parkin to dysfunctional mitochondria. USP8 was also reported to be post-translationally modified by sulfhydration in response to H2S treatment, easing its interaction with parkin and facilitating mitochondrial docking in a cardiomyopathy db/db mouse model [101,102]. This evidence concerns the gene USP8 and cardiomyopathy.