Moreover, linking cell death to inflammation, NASH patients and experimental NASH animal models revealed a striking inflammasome activation in different parenchymal and non-parenchymal cells with expression of inflammasome-associated genes including nod-like receptor protein 3 (NLRP3), pro-iL-18, pro-IL-1β, ASC and caspase-1 [40]. This evidence concerns the gene IL1B and metabolic dysfunction-associated steatohepatitis.