The pathogenesis of inflammatory bowel disease (IBD) may be characterized by a loss of intestinal epithelial integrity and the dysregulation of several proteins, including transmembrane proteins, such as zona occludens (ZO)-1, occludin, claudins, and tight junctional molecules [28,29,30], in DSS-induced acute colitis mice [31]. This evidence concerns the gene OCLN and inflammatory bowel disease.