JAK1 and neoplasm: Likewise, the medium and high doses of TAM significantly decreased the expression of p-JAK1 and p-STAT6 in the tumor tissues compared to that of the untreated control group, and the effect was stronger than that of TMZ (Figure 7C,D), as detected by Western blotting (Figure S3B) and immune histology chemistry (IHC) (Figure S4).