They should have no contraindications for medical treatment and a histological diagnosis of grade I EC; histotype: endometrioid with positive hormone receptor (type I), tumour diameter < 2.0 cm, stage IA without myometrial and adnexal involvement, negative lymph-vascular space invasion, and diffuse immunohistochemical expression of progesterone receptors on endometrial biopsy. This evidence concerns the gene NR4A1 and neoplasm.