Additional experiments showed that TET1 expression and 5-hmC levels were easily detectable in human colon tissues and in normal epithelial colon cells (CCD), whereas no detectable levels of TET1 transcript or 5-hmC were observed in five different colorectal cancer cell lines (Colo205, HCT116, HT29, SW48, and Caco-2). The gene discussed is TET1; the disease is colorectal cancer.