This classifier also performed better than the conventional biomarkers (including carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), carbohydrate antigens (CA125, CA15-3, CA19-9, and CA72-4), cytokeratin 19, and neuron-specific enolase (NSE)) and epidemiological risk factors (including indices of overweight, obesity, and alcohol consumption and previous history of cancer) when predicting colorectal cancer. This evidence concerns the gene AFP and colorectal cancer.