The oncogenic roles of PSMD14 in various cancers have been associated with its effect on deubiquitinating and stabilizing various protein substrates, including ErbB2 [36], E2F1 [37,38], TGF-beta receptors, caveolin-1 [39], GRB2 [40], and SNAIL [9], suggesting that targeting PSMD14 could be a promising strategy for cancer treatment. This evidence concerns the gene E2F1 and cancer.