Here, we report that the silencing and pharmacological inhibition of PSMD14 induce paraptosis, a non-apoptotic cell death mode characterized by extensive vacuolation derived from the dilations of the endoplasmic reticulum (ER) and mitochondria [14,15], in various breast cancer cells but not in the MCF-10A human breast epithelial cell line. The gene discussed is PSMD14; the disease is breast carcinoma.