Consistent with the role of FGF-2 secreted by astrocytes in angiogenesis in physiological conditions that we previously described, it is possible to propose that in the tumoral microenvironment the glioma cells induce even a greater increase in FGF-2 in astrocytes, promoting angiogenesis through FGF signaling in ECs and account for the high grade of vascularization of glioblastomas. Here, FGF2 is linked to glioma.