Interestingly, when a treatment with antibodies against VEGF was used, despite the reduction in tumoral angiogenesis, an increase of infiltrating tumor cells correlated with an increase of HIF expression in glioma cells was observed [145], suggesting that hypoxic environment due loss of angiogenesis and mechanisms dependent on HIF-1 signaling could account for tumor progression in invasive areas. This evidence concerns the gene VEGFA and central nervous system cancer.