As described in Section 2.1, N-cadherin reduction has been associated with oligodendrocytes migration through astrocyte template [18], and it is possible to suggest that an initial disruption of N-cadherin signaling in glioma cells allow them to migrate using the astrocytic template, and then an increase of N-cadherin expression reestablish cell to cell contacts between these cells or with astrocytes, promoting resistance to the treatments. The gene discussed is CDH2; the disease is central nervous system cancer.