Collectively, the importance of polyploidization [54,123] and EGFR downstream activation of YAP1 in response to AKI [114] may indicate that blocks of EGFR could profoundly affect the endogenous repair potential of the kidney, especially when administered in combination with cytotoxic agents that are notoriously nephrotoxic, exacerbating their damage. The gene discussed is YAP1; the disease is acute kidney injury.