INS and polycystic ovary syndrome: Such re-interpretation of ovarian pathophysiology in PCOS-like monkeys, through proposed impairments in insulin signaling in theca, granulosa or stromal cells (or a combination of all three), would agree with in vivo studies in PCOS women showing enhanced, rather than diminished, ovarian steroidogenic responses to FSH following insulin sensitizer treatment [107,113,114].