There were also no insulin treatment effects on steroid hormone ratios (Table 5) indicating relatively similar LH/CG receptor driven ovarian androgen biosynthesis (androstenedione to DHEA ratio), progesterone biosynthesis (progesterone to estradiol ratio) and aromatization of testosterone to estradiol (estradiol to testosterone ratio) in control compared to PCOS-like monkeys, regardless of treatment. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.