Intensive insulin treatment may sufficiently compensate for impaired insulin action, thus providing effective co-gonadotropin support for steroidogenic and other functions with PCOS-like monkey ovaries, analogous to the unexpected effects of intensive (high dose) exogenous insulin treatment overcoming insulin resistance with regard to glucoregulation in T2D humans (at least 6 months of treatment) [110,111]. The gene discussed is INS; the disease is polycystic ovary syndrome.