INS and type 2 diabetes mellitus: These daily doses of humulin U ultralente resemble those given in partial insulin treatment of naturally occurring T2D in adult rhesus monkeys at Wisconsin National Primate Research Center (WNPRC) (6–20 U/day), and these diabetic animals also received the same daily dose of intermediate-acting human insulin (NPH) [77], and both insulin preparations and diluent were clinically approved for use when this study was undertaken.