Clinical studies of obese women with PCOS, employing weight loss programs [25,26,27], bariatric surgery [28], insulin-sensitizing agents in obese and non-obese patients [24,29,30,31,32], anti-androgens [33,34] and mental health intervention [35], have diminished insulin resistance and improved ovulatory function. This evidence concerns the gene INS and polycystic ovary syndrome.