We evaluated the roles of BRCA associated protein-1 (<i>BAP1</i>) and cyclin-dependent kinase inhibitor 2A (<i>CDKN2A</i>) in colon cancer and mesothelioma to support the hypothesis that <i>BAP-1</i> and <i>CDKN2A</i> are tumour suppressor genes involved in disease progression, recurrence, or death in both digestive cancers and mesothelioma. The gene discussed is CDKN2A; the disease is colonic neoplasm.