ESR1 and lung adenocarcinoma: We calculated PAL levels for the “top-10” such pathways for Lung Adenocarcinoma biosamples (Figure 14) and compared activation charts for the chosen “AHR Pathway PS2 Gene expression via ESR” and “reactome Acetylcholine Neurotransmitter Release Cycle Main Pathway” pathways, which have the highest and the lowest correlations, respectively, for Lung Adenocarcinoma (Figure 15).