The 2017 American Urological Association and 2019 ESMO clinical practice guidelines recommend the prompt use of laboratory examinations to study a suspicious RCC and suggest performing the following tests: serum creatinine, estimated glomerular filtration rate using the MDRD or CKD-EPI equation, complete blood count, lymphocyte to neutrophil ratio, lactate dehydrogenase, C-reactive protein, serum-corrected calcium, urinalysis by dipstick and microscopic evaluation to detect proteinuria, hematuria, pyuria and other urinary abnormalities [105,120]. This evidence concerns the gene CRP and renal cell carcinoma.