MTOR and hepatocellular carcinoma: Furthermore, this study confirmed that a significantly increased number of GPER1 receptors was detected in HCC (hepatocellularcarcinoma) tissues, and their contact with E2 via the phos-phoinositide 3-kinase-protein kinase B-mechanistic target of rapamycin pathway and PI3K-mTOR can induce and significantly accelerate hepatocarcinogenetic processes in male zebrafish.