The interaction of DAMPs with RAGE receptors activates NFκB via AKT, ERK, and p38 signaling pathways, actuating the transcription of cytokines, chemokines and other inflammatory mediators (CCL2, CCL5, CXCL10, CXCL12 TNF-α, IL-1β, IL6, ICAM-1, VCAM-1, NOS-2) [110,263] involved in retinal disorders (Figure 1). Here, NFKB1 is linked to retinal disorder.