The localization of HS in Bruch’s membrane (BM) in AMD describes its regulatory role of CNV mainly via its interaction with various angiogenic growth factors, including fibroblast growth factor (FGF), VEGF, TNF-α, TGF-β, and interferon (IFN)-γ [207]. The gene discussed is TGFB1; the disease is age-related macular degeneration.