In the light-induced retinal degeneration animal model, HMGB2 causes photoreceptor cell death by down-regulating nuclear factor erythroid 2-related factor/heme oxygenase-1 (Nrf2/HO-1) and up-regulating NFκB/NLRP3 signaling inflammatory pathways [200]. This evidence concerns the gene HMOX1 and retinal degeneration.