DAMPs function through multiple specialized innate immune receptors, such as receptors for advanced glycation end products (RAGE), toll-like receptors (TLRs) and the NOD-like receptor (NLRs) family, purine receptor 7 (P2X7), NLR pyrin domain 3 (NLRP3), in retinal disorders [1,10,11,12]. The gene discussed is AGER; the disease is retinal disorder.