In contrast, in the animal model of sepsis-induced ALI, different statins attenuated inflammatory injury and apoptosis in pulmonary parenchyma, enhanced antioxidant enzymes, and improved endothelial permeability and the level of junction proteins through regulating different pathways, such as Cav-1/eNOS or TLR4/NF-kB [14,15,18,27]. This evidence concerns the gene NFKB1 and Sepsis.