In particular, they demonstrated that the levels of peptidyl-prolyl cis-trans isomerase A (PPIA), heat shock cognate protein 71 kDa (HSC70), heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) and TDP-43 significantly differed between ALS patients and healthy controls [42]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.