BACE1 and Alzheimer disease: On the other hand, Bhattacharyya et al., (2013) and Zaręba-Kozioł et al., (2018), suggested that APP palmitoylation enhances Aβ peptide production through the amyloidogenic pathway and the dysregulation of palmitoylation in AD, due to Aβ oligomers being derived from the sequential proteolytic processing of APP using different enzymes, including BACE1, β-secretase, and γ-secretase [84,194].