NLGN3 and fragile X syndrome: Hamilton et al. [42] generated two rat models for ASD, one syndromic and one non-syndromic model, through the ZFN system, by destroying a gene (Fmr1) coding the Fragile X mental retardation protein (FMRP), the protein responsible for the pathogenesis of Fragile X syndrome (FXS), or a gene (Ngln3) coding for Neuroligin3 (NLGN3), a member of the neuroligin synaptic cell-adhesion protein family, respectively.