AGXT and primary hyperoxaluria type 1: Primary hyperoxaluria type 1 (PH1) is an inherited disease caused by mutations in the mitochondrial localized alanine-glyoxylate aminotransferase (Agxt) gene, leading to abnormal metabolism of glyoxylic acid in the liver, subsequent endogenous oxalate overproduction, and deposition of oxalate in multiple organs, mainly the kidney.