SASP regulatory mechanisms in senescent CD4+ T lymphocytes: To determine the molecular mechanisms involved in SASP production by senescent CD4+ T lymphocytes purified from periodontitis-affected tissues, it is possible to use p38 MAPK, ROS, and/or autophagy inhibitors and evaluate their influence on the production of pro-inflammatory mediators, thus elucidating the main regulators orchestrating SASP production in these cells. Here, CD4 is linked to periodontitis.