In this study, the use of EVs from hUCT-derived MSCs and hUCB-derived eCD133+ cells prevent the progress of kidney damage in an adenine-induced renal injury model, which were demonstrated in albumin and serum cystatin C analyses, α-SMA labeling, and despite showing less significant expression only in the MSC-EV group, there was also an improvement in the eEPC-EV group. This evidence concerns the gene ALB and Nephropathy.