AKT1 and triple-negative breast carcinoma: Herbal formulations consisting of multiple Chinese nutritional herbs are widely used in traditional Chinese medicine for treatment of triple negative breast cancer (TNBC) and their growth inhibitory efficacy is predominantly via inhibition of Phospho-inositidyl-3 kinase (PI3K), protein kinase B (AKT), molecular target of rapamycin (mTOR), mitogen activated protein kinase (MAPK) and Wnt/β-catenin pathways [36].