Despite a more profound inflammation in Candida-5/6Nx than non-Candida 5/6Nx, L34 attenuated disease severity in these mice, as indicated by renal injury (improve renal fibrosis and proteinuria, but not serum creatinine), gut barrier defect (FITC-dextran, but not LPS and BG), gut-derived uremic toxins (TMAO and IS), systemic inflammation (serum cytokines), and liver damage (ALT). The gene discussed is GPT; the disease is renal fibrosis.