Starting with the information that is currently available, respectively MDSCs numbers elevated in the circulation of GBM patients and reversible T cell dysfunction at that level, Raychaudhuri B. et al., used sunitinib, a tyrosine kinase inhibitor, to treat mouse brain tumor models and reported an overall decrease in granulocytic and monocytic MDSCs, enhanced T cell proliferation, and IFNγ production, all of which are linked to tumor shrinkage and better survival. The gene discussed is IFNG; the disease is neoplasm.