HIF1A and central nervous system cancer: CXCL8 expression levels were observed to be strongly related to progression and poor prognosis in human glioma, according to Chen Z. et al., According to his research, CXCL8 accelerated the epithelial-mesenchymal transition in glioma cells via activating the JAK/STAT1/HIF-1/Snail signaling pathway [189].