Overexpression of Romo1 in bone marrow cells, for example, substantially reduced the immune response within the tumor microenvironment and facilitated glioblastoma progression, showing that overexpression of Romo1 (reactive oxygen species modulator 1) in macrophages may be an essential mechanism of immunological tolerance for glioblastoma [265]. Here, ROMO1 is linked to glioblastoma.