Pro-inflammatory cytokines (IL-6), anti-apoptotic proteins from the Bcl-2 family (Bcl-xL), or proteolytic enzymes (MMP-2 and -9) determine the increase of CXCL8-CXCR1/2 protein expression and its promoter activity in glioblastoma cells. This evidence concerns the gene IL6 and glioblastoma.