Mutations in arachidonate 12-lipoxygenase, 12R type (ALOX12B), arachidonate lipoxygenase 3 (ALOXE3), NIPA-like domain containing 4 (NIPAL4)/ichthyin, patatin like phospholipase domain containing 1 (PNPLA1) and cytochrome P450 family 4 subfamily F member 22 (CYP4F22) genes are associated with the development of non-bullous congenital ichthyosiform erythroderma (NBCIE; OMIM #242100, OMIM #606545, OMIM #612281, OMIM #615024, OMIM #604777) [4,5]. The gene discussed is NIPAL4; the disease is congenital non-bullous ichthyosiform erythroderma.