In in vitro model of keratinocytes of a patient with epidermolytic ichthyosis caused by the mutations in the KRT1 or KRT10 genes, and in in vivo xenograft NOD/SCID mice, it was shown that TALEN specifically affects the KRT10 region and leads to the complete degradation of mRNA encoded from the mutant KRT10 gene, restoration of intermediate filament stability and changes in cellular and histological phenotypes [107]. This evidence concerns the gene KRT10 and autosomal dominant epidermolytic ichthyosis.