SPINK5 and Netherton syndrome: To date, one clinical trial (NCT01545323) dedicated to the transplantation of skin graft genetically modified with a lentiviral vector encoding a functional copy of the serine peptidase inhibitor kazal type 5 (SPINK5) gene required for the formation of lympho-epithelial kazal-type-related inhibitor (LEKTI) protein in skin stem cells in Netherton Syndrome has been described.