In addition, an upregulation of T-helper (Th) type 17 pathway genes (IL17F and IL36B/G) and IL-17-related proteins synergistically induced by IL-17 and tumor necrosis factor (TNF)-α (IL-17A/C, IL-19, CXC motif chemokine ligand 1 (CXCL1), peptidase inhibitor 3 (PI3), chemokine (CC motif) ligand 20 (CCL20)) in the cells of patients with different types of ARCI, which correlates with the severity of the disease, was observed [48]. Here, TNF is linked to autosomal recessive congenital ichthyosis.