The ROC curves for IgG antibodies (Figure 5) resulted in low area under the curve (AUC) values of 0.51 for NGP antibodies and 0.53 for DGP antibodies in the absence of anti-TG2 antibody positivity, and could not distinguish, at any NGP or DGP concentrations, subjects who later developed CeD or did not. This evidence concerns the gene TGM2 and cranioectodermal dysplasia.