On the molecular level, the expression of the target protein CDK7 is significantly down-modulated under the conditions of CDK7-/pUL97-directed synergistic drug treatment, and the functional importance of these two cyclin H-associated target kinases is specifically measurable in HCMV infection settings using ORF-UL97-deleted virus or cellular cyclin knock-out. The gene discussed is CCNH; the disease is cytomegalovirus infection.