Several mechanisms are implicated in the pathophysiology of Alzheimer’s disease, including Aβ deposition [152], tau hyperphosphorylation [152], neuroinflammation [150], constriction of brain capillaries [153], Aβ interaction with hippocampal ghrelin/GHSR1α signalling [154], DNA damage [155], disrupted RNA hemostasias [156], mitochondrial dysfunction [157], endoplasmic reticulum (ER) stress [158], and proteostasis dysfunction [159]. The gene discussed is MAPT; the disease is Alzheimer disease.