This, together with the altered adipokine secretions from WAT in obesity, (i.e., the decreased secretion of adiponectin, increased secretion of leptin, IL-6, resistin, plasminogen activator inhibitor type 1, and monocyte chemotactic protein-1 (MCP-1) [126,127]) activates cell-signaling pathways in breast cancer cells that are correlated with growth, proliferation, EMT, migration, and invasion [69,83,106,107,108]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.