Nitric oxide synthase (iNOS) is increased in MS patients, supporting MS pathogenesis, mainly inhibiting the mitochondrial respiratory chain. Agmantine is an NO inhibitor that shows activity against MS in vivo, and it should be considered within the integral treatment of MS. Moreover, hydralazine decreases the accumulation of LA and is a promising drug in the complementary treatment of MS. Here, NOS2 is linked to myeloid sarcoma.