Proton-gated, acid-sensing ion channels (ASICs), mainly the isoform ASIC1, favor the excessive intracellular accumulation of Na+, Ca++, and H+ in MS and other HNDDs, resulting in severe neural damage, secondary to Ca++ overload and acidification-mediated apoptosis [45,46] (Figure 2). Here, ASIC1 is linked to myeloid sarcoma.