NaV1.5 Na+ channels associate with NHE1 to become overexpressed in breast cancer, stimulating the formation of invadopodia and the metastatic process. The utilization of voltage-gated IO-inhibiting drugs has been shown to increase survival in cancer patients. Additionally, they also have the potential to be used as a therapeutic option in MS and HNDDs. This evidence concerns the gene SCN5A and breast cancer.