Removal of essential GFs result in apoptosis. NHE activity is fundamental in the pH regulation of the CNS, normalizing neural homeostasis by stimulating cellular metabolism and DNA synthesis. PDGF has been shown to induce an important decrease in brain amyloid-β (Aβ) deposition and tau phosphorylation in a mice model of AD, also reducing inflammatory responses and promoting Aβ degradation. The gene discussed is MAPT; the disease is Alzheimer disease.