In 2000, working on a transcriptome-wide study of gene expression in cell lines sensitive and resistant to anticancer drugs, Takashi Tsuruo and colleagues—who discovered the role of P-glycoprotein in multidrug resistance (MDR) in cancer chemotherapy [101], found a further important factor in cancer chemotherapy MDR was increased Glo1 expression [102]. Here, ABCB1 is linked to cancer.