If the anti-inflammatory effects of tRES-HESP on gene expression in PBMCs translate to tissues, there may be additional health benefits of tRES-HESP through a decrease in low-grade inflammation in NAFLD [8,9,10], chronic kidney disease [11,12], and decline of respiratory function [13,14,15], cardiovascular disease, and aging [16,17,18]. The gene discussed is TMPRSS11A; the disease is cardiovascular disorder.