VEGFA and systemic sclerosis: As described in [141] an HRV impairment is indeed found to be associated with microvascular damage assessed through the nailfold videocapillaroscopy of SSc patients and, interestingly, a study performed on twenty-seven SSc patients found a positive correlation between digital microvascular damage and parasympathetic modulation that promoted VEGF release to stimulate vasodilatation [142].