PSEN2 and Alzheimer disease: We analyzed SIRT and HDAC3 expression and activity, the expression of several AD-related genes (PSEN1, PSEN2, APOE), pro-inflammatory (COX-2, TNF-α, and IL-6), and apoptotic (NOS3) markers, and immunoreactivity for glial fibrillary acidic protein (GFAP), CD11b and β-amyloid.