We therefore analyzed HDAC activity and HDAC3 mRNA levels in wild-type and APP/BIN1/COPS5 3xTg-AD mice; HDAC activity and HDAC3 mRNA expression increased by approximately 40% in the hippocampus from APP/BIN1/COPS5 3xTg-AD mice (Figure 5A,B). This evidence concerns the gene BIN1 and Alzheimer disease.