TLR4 is the most studied and involved TLR in the aetiology of hypertension [95], based on the well-known association between TLR4 and angiotensin II, identified by some authors as DAMP [95,107] and demonstrated in various experimental models of hypertension, such as SHRs [108] or rats with angiotensin II-induced hypertension [109]. Here, TLR4 is linked to hypertensive disorder.