In addition, Ang II and aldosterone have been linked to the production of reactive oxygen species (ROS), which are known to represent key mediators of cerebrovascular dysfunction in arterial hypertension, as they contribute to vasorarefaction (loss of arterioles and capillaries) and the structural remodelling of cerebral blood vessels, resulting in chronic hypoperfusion of the brain. This evidence concerns the gene AGT and Hypertension.