SERPINA1 and liver disorder: Clinical trials assessing RNAi candidates, ARC-AAT (NCT02363946), ALN-AAT (NCT02503683), ALN-AAT02 (NCT03767829) as a potential therapeutic for AAT-mediated liver disease were terminated in 2016, 2018 and 2020 based on toxicity concerns in non-human primate studies, low incidence of asymptomatic, transiently elevated liver enzymes in a subset of study subjects and sponsor decision, respectively.